Description of position DC08
Title of the project
Supramolecular protecting groups for carbohydrate synthesis
Description of the project
In this project, we will use macrocycles, provided by members of the ENSCC network, for selective temporary protection of hydroxy groups on various carbohydrates. The substrates will be common carbohydrates with a minimum of protective groups. The temporally non-covalent “protection/activation” by the interaction with the macrocycle will allow for selective chemical derivatization of specific hydroxy groups, giving site-selective modifications. This could, as examples be the installment of protective groups like esters, glycosylations or oxidation reactions. Initial studies will be performed using already available macrocycles, but in time, new types of macrocycles will be developed based on the results obtained. Some initial screening of host-guest interactions will be performed at UCPH and followed up by members of the ENSCC network.
Research Field
Main area:Carbohydrate chemistry, Supramolecular chemistry, Analytical chemistry
Specific area: Organic synthesis, NMR studies, Protective group manipulation, Glycosylation chemistry
Work location
Department of Chemistry, University of Copenhagen. www.ki.ku.dk
Pedersen Laboratory: https://chem.ku.dk/research_sections/orgchem/pedersen-laboratory/
Supervisor
prof. Christian Marcus Pedersen (cmp@chem.ku.dk)
Required educational level
It is expected that the candidate has a master’s degree with in the topics organic chemistry and/or carbohydrate chemistry
Skills or qualitfication required
Experience with organic synthesis and carbohydrate chemistry.
Tentative starting date of the contract
01/09/2024
Eligibility Criteria
Eligibility criteria available here.
Additional steps for the application
Candidates interested in applying for this specific position must submit their application according to the instructions provided on this website. Additionally, they are required to submit their application through the UPCH webpage, accessible at the following link. It is important to note that applications not present on both platforms will not be considered valid.
