Description of position DC11
Title of the project
Macropolycyclic hydrogen bonding cages for carbohydrate recognition in water
Description of the project
With inspiration from the remarkable glucose receptor GluHUT (see Nature Chem, 2019, 11, 52-56), we aim to develop cage molecules which bind a variety of carbohydrates of medical relevance. In particular we will target the many carbohydrates which, unlike glucose, possess axial substituents. Advanced computational chemistry methods will assist with the design work. Organic synthesis will be central to the project, and NMR will be used extensively to assess binding properties.
Research Field
Main area: Synthetic Supramolecular Chemistry
Specific area: Carbohydrate Recognition
Work location
School of Chemistry, University of Bristol, Bristol BS8 1TS. https://www.bristol.ac.uk/, https://davis.chm.bris.ac.uk/
Supervisor
prof. Anthony P. Davis (Anthony.Davis@bristol.ac.uk)
Required educational level
Chemistry or a closely related topic
Skills or qualitfication required
Knowledge and understanding of organic chemistry and experience in organic chemical research
Required English level
A satisfactory English level is a strict requirement, see https://www.bristol.ac.uk/study/language-requirements/profile-f/
Tentative starting date of the contract
01/09/2024
Eligibility Criteria
Eligibility criteria available here.
